Chemometric strategies for enhancing the chromatographic methodologies with second-order data analysis of compounds when peaks are overlapped

This overview covers the different chemometric strategies linked to chromatographic methodologies that have been used and presented in the recent literature to cope with problems related to incomplete separation, the presence of unexpected components in the sample, matrix effect and changes in the a...

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Bibliographic Details
Published in:Talanta (Oxford) 2011-01, Vol.83 (4), p.1098-1107
Main Authors: Goicoechea, H.C., Culzoni, M.J., García, M.D. Gil, Galera, M. Martínez
Format: Article
Language:English
Subjects:
Algorithms
Calibration
Chemometrics
Chromatography
Chromatography - methods
Chromatography - standards
Informatics - methods
Reference Standards
Second-order data
Signal pre-treatment
Spectrum Analysis
Statistics as Topic - methods
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Summary:This overview covers the different chemometric strategies linked to chromatographic methodologies that have been used and presented in the recent literature to cope with problems related to incomplete separation, the presence of unexpected components in the sample, matrix effect and changes in the analytical signal due to pre-treatment of sample. Among the different chemometric strategies it focuses on pre-treatment of data to correct background and time shift of chromatographic peaks and the use of second-order algorithms to cope with overlapping peaks from analytes or from analytes and interferences in liquid chromatography coupled to diode array, fast-scanning fluorescence spectroscopy and mass spectrometry detectors. Finally the review presents the strategies used to deal with changes in the analytical response as result of matrix effect in liquid and gas chromatography, as well as the use of standardization strategies to correct modifications in the analytical signal as a consequence of sample pre-treatment in liquid chromatography.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2010.07.057