Effect of passive smoking on blood lymphocyte apoptosis in children

Eur J Clin Invest 2011; 41 (4): 387–392 Background  Passive smoking is a well‐known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points...

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Bibliographic Details
Published in:European journal of clinical investigation 2011-04, Vol.41 (4), p.387-392
Main Authors: El-Hodhod, Moustafa A., Hamdy, Ahmed M., Ahmed, Manal B., Youssef, Soha R., Aly, Shaimaa M. H.
Format: Article
Language:English
Subjects:
Adolescent
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Case-Control Studies
Child
Child, Preschool
Children
General aspects
Humans
Lipid Metabolism - drug effects
lipid profile
lymphocyte apoptosis
Lymphocytes - drug effects
Male
Medical sciences
passive smoking
Risk
Risk Factors
Tobacco Smoke Pollution - adverse effects
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Summary:Eur J Clin Invest 2011; 41 (4): 387–392 Background  Passive smoking is a well‐known risk factor for both recurrent respiratory infections and disturbed lipid profile. Whether passive smoking problems are related to altered lymphocyte survival and its relation to altered lipid profile are the points of concern in this work. Materials and methods  Urinary cotinine and creatinine levels as well as lipid profile and flow cytometric assessment of apoptosis of peripheral blood lymphocytes (PBL) were assessed in 26 children with history of indoor exposure to cigarette smokers in comparison with 14 matched children with no such history. Results  Lipid profile showed significantly higher mean levels of triglycerides, cholesterol and low‐density lipoprotein (LDL) and significantly lower mean levels of high‐density lipoprotein (HDL) in passive smoking children compared to nonpassive‐smoking ones. Furthermore, cotinine parameters were positively correlated with triglycerides and LDL and negatively correlated with HDL. Early apoptosis of PBL was significantly higher in exposed vs nonexposed ones. Conclusions  Passive smoking in children could be a risk factor for enhanced lymphocytic apoptosis. It is possible that altered lipid profile may play a role in the increased risk. The impact of this lymphocytic derangement on increased frequency of infections is noticeable.
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2010.02420.x