Effects of Extremely Low-Frequency Magnetic Field on Caspase Activities and Oxidative Stress Values in Rat Brain

This study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500 µT ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Br...

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Bibliographic Details
Published in:Biological trace element research 2010-12, Vol.138 (1-3), p.238-249
Main Authors: Akdag, Mehmet Zulkuf, Dasdag, Suleyman, Ulukaya, Engin, Uzunlar, Ali Kemal, Kurt, Mustafa Ayberk, Taşkın, Abdullah
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Apoptosis
Biochemistry
Biomedical and Life Sciences
Biotechnology
Brain
Brain - enzymology
Brain - metabolism
Brain - radiation effects
Caspase 3 - metabolism
Caspase-3
Catalase
Electromagnetic Fields
Life Sciences
Low frequency
Magnetic fields
Male
Malondialdehyde
Malondialdehyde - metabolism
Nutrition
Occupational exposure
Oncology
Oxidants
Oxidative stress
Oxidative Stress - radiation effects
Oxidizing agents
Peroxidase
Rats
Rats, Sprague-Dawley
Rodents
Stress analysis
Toxicity
Trace elements
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Summary:This study was aimed to investigate the effect of extremely low-frequency magnetic field (ELF-MF) on apoptosis and oxidative stress values in the brain of rat. Rats were exposed to 100 and 500 µT ELF-MF, which are the safety standards of public and occupational exposure for 2 h/day for 10 months. Brain tissues were immunohistochemically stained for the active (cleaved) caspase-3 in order to measure the apoptotic index by a semi-quantitative scoring system. In addition, the levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat brain. Final score of apoptosis and MPO activity were not significantly different between the groups. CAT activity decreased in both exposure groups (p 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-010-8615-3