Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy

Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed...

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Bibliographic Details
Published in:Epilepsy research 2011-03, Vol.94 (1), p.117-120
Main Authors: Freitas-Lima, Priscila, Alexandre, Veriano, Pereira, Leonardo Regis Leira, Feletti, Fausto, Perucca, Emilio, Sakamoto, Americo Ceiki
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anticonvulsants - blood
Anticonvulsants - pharmacokinetics
Anticonvulsants - therapeutic use
Anticonvulsants. Antiepileptics. Antiparkinson agents
Area Under Curve
Biological and medical sciences
Case-Control Studies
Drug interaction
Enzyme induction
Enzyme Induction - drug effects
Epilepsy
Epilepsy - drug therapy
Epilepsy - enzymology
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Levetiracetam
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacokinetics
Pharmacology. Drug treatments
Piracetam - analogs & derivatives
Piracetam - blood
Piracetam - pharmacokinetics
Piracetam - therapeutic use
Time Factors
Young Adult
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Summary:Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance ( p = 0.01) and a shorter half-life ( p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2011.01.007