Loading…
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed...
Saved in:
| Published in: | Epilepsy research 2011-03, Vol.94 (1), p.117-120 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323 |
| container_end_page | 120 |
| container_issue | 1 |
| container_start_page | 117 |
| container_title | Epilepsy research |
| container_volume | 94 |
| creator | Freitas-Lima, Priscila Alexandre, Veriano Pereira, Leonardo Regis Leira Feletti, Fausto Perucca, Emilio Sakamoto, Americo Ceiki |
| description | Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance ( p = 0.01) and a shorter half-life ( p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients. |
| doi_str_mv | 10.1016/j.eplepsyres.2011.01.007 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_856775132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0920121111000118</els_id><sourcerecordid>856775132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323</originalsourceid><addsrcrecordid>eNqNkt-L1DAQx4Mo3nr6L0hexKeuM2m7TV8EPfxxcOCD-hyy6fQ2e21aM-1J_etN2dUDn4SBBPL5fmf4ZoSQCFsE3L05bmnsaOQlEm8VIG4hFVSPxAZ1pbKdLorHYgO1ggwV4oV4xnyEREBRPBUXCpVWUOBG8HVou5mCIzm0ksKvpSfpQzM7H26lDZOn0adWk3eyifMtyyHI6UByPNjYWzfc-UDpkVd5R_fpHq2jyfbJRY426cPE8qefDvLkxMtz8aS1HdOL83kpvn_88O3qc3bz5dP11bubzBWlnjKd6xqgVHmLGqtKK6tVgwjgyppqsvm-VtQ0e5dDScpSo4CoQFUo0ApzlV-K1yffMQ4_ZuLJ9J4ddZ0NNMxsdLmrqvJE6hPp4sAcqTVj9L2Ni0Ewa-LmaB4SN2viBlJBlaQvz03mfU_NX-GfiBPw6gxYdrZrow3O8wOX17syjZG49yeOUiT3nqJh59ePaXwkN5lm8P8zzdt_TFzng09972ghPg5zDClyg4aVAfN13ZB1QdZYk43OfwPtArq3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>856775132</pqid></control><display><type>article</type><title>Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy</title><source>ScienceDirect Journals</source><creator>Freitas-Lima, Priscila ; Alexandre, Veriano ; Pereira, Leonardo Regis Leira ; Feletti, Fausto ; Perucca, Emilio ; Sakamoto, Americo Ceiki</creator><creatorcontrib>Freitas-Lima, Priscila ; Alexandre, Veriano ; Pereira, Leonardo Regis Leira ; Feletti, Fausto ; Perucca, Emilio ; Sakamoto, Americo Ceiki</creatorcontrib><description>Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance ( p = 0.01) and a shorter half-life ( p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.</description><identifier>ISSN: 0920-1211</identifier><identifier>EISSN: 1872-6844</identifier><identifier>DOI: 10.1016/j.eplepsyres.2011.01.007</identifier><identifier>PMID: 21282041</identifier><identifier>CODEN: EPIRE8</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Anticonvulsants - blood ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Area Under Curve ; Biological and medical sciences ; Case-Control Studies ; Drug interaction ; Enzyme induction ; Enzyme Induction - drug effects ; Epilepsy ; Epilepsy - drug therapy ; Epilepsy - enzymology ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Levetiracetam ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pharmacokinetics ; Pharmacology. Drug treatments ; Piracetam - analogs & derivatives ; Piracetam - blood ; Piracetam - pharmacokinetics ; Piracetam - therapeutic use ; Time Factors ; Young Adult</subject><ispartof>Epilepsy research, 2011-03, Vol.94 (1), p.117-120</ispartof><rights>Elsevier B.V.</rights><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323</citedby><cites>FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23965775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21282041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas-Lima, Priscila</creatorcontrib><creatorcontrib>Alexandre, Veriano</creatorcontrib><creatorcontrib>Pereira, Leonardo Regis Leira</creatorcontrib><creatorcontrib>Feletti, Fausto</creatorcontrib><creatorcontrib>Perucca, Emilio</creatorcontrib><creatorcontrib>Sakamoto, Americo Ceiki</creatorcontrib><title>Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy</title><title>Epilepsy research</title><addtitle>Epilepsy Res</addtitle><description>Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance ( p = 0.01) and a shorter half-life ( p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anticonvulsants - blood</subject><subject>Anticonvulsants - pharmacokinetics</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Drug interaction</subject><subject>Enzyme induction</subject><subject>Enzyme Induction - drug effects</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - enzymology</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Levetiracetam</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Piracetam - analogs & derivatives</subject><subject>Piracetam - blood</subject><subject>Piracetam - pharmacokinetics</subject><subject>Piracetam - therapeutic use</subject><subject>Time Factors</subject><subject>Young Adult</subject><issn>0920-1211</issn><issn>1872-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqNkt-L1DAQx4Mo3nr6L0hexKeuM2m7TV8EPfxxcOCD-hyy6fQ2e21aM-1J_etN2dUDn4SBBPL5fmf4ZoSQCFsE3L05bmnsaOQlEm8VIG4hFVSPxAZ1pbKdLorHYgO1ggwV4oV4xnyEREBRPBUXCpVWUOBG8HVou5mCIzm0ksKvpSfpQzM7H26lDZOn0adWk3eyifMtyyHI6UByPNjYWzfc-UDpkVd5R_fpHq2jyfbJRY426cPE8qefDvLkxMtz8aS1HdOL83kpvn_88O3qc3bz5dP11bubzBWlnjKd6xqgVHmLGqtKK6tVgwjgyppqsvm-VtQ0e5dDScpSo4CoQFUo0ApzlV-K1yffMQ4_ZuLJ9J4ddZ0NNMxsdLmrqvJE6hPp4sAcqTVj9L2Ni0Ewa-LmaB4SN2viBlJBlaQvz03mfU_NX-GfiBPw6gxYdrZrow3O8wOX17syjZG49yeOUiT3nqJh59ePaXwkN5lm8P8zzdt_TFzng09972ghPg5zDClyg4aVAfN13ZB1QdZYk43OfwPtArq3</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Freitas-Lima, Priscila</creator><creator>Alexandre, Veriano</creator><creator>Pereira, Leonardo Regis Leira</creator><creator>Feletti, Fausto</creator><creator>Perucca, Emilio</creator><creator>Sakamoto, Americo Ceiki</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy</title><author>Freitas-Lima, Priscila ; Alexandre, Veriano ; Pereira, Leonardo Regis Leira ; Feletti, Fausto ; Perucca, Emilio ; Sakamoto, Americo Ceiki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anticonvulsants - blood</topic><topic>Anticonvulsants - pharmacokinetics</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Drug interaction</topic><topic>Enzyme induction</topic><topic>Enzyme Induction - drug effects</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - enzymology</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Levetiracetam</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Piracetam - analogs & derivatives</topic><topic>Piracetam - blood</topic><topic>Piracetam - pharmacokinetics</topic><topic>Piracetam - therapeutic use</topic><topic>Time Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freitas-Lima, Priscila</creatorcontrib><creatorcontrib>Alexandre, Veriano</creatorcontrib><creatorcontrib>Pereira, Leonardo Regis Leira</creatorcontrib><creatorcontrib>Feletti, Fausto</creatorcontrib><creatorcontrib>Perucca, Emilio</creatorcontrib><creatorcontrib>Sakamoto, Americo Ceiki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freitas-Lima, Priscila</au><au>Alexandre, Veriano</au><au>Pereira, Leonardo Regis Leira</au><au>Feletti, Fausto</au><au>Perucca, Emilio</au><au>Sakamoto, Americo Ceiki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy</atitle><jtitle>Epilepsy research</jtitle><addtitle>Epilepsy Res</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>94</volume><issue>1</issue><spage>117</spage><epage>120</epage><pages>117-120</pages><issn>0920-1211</issn><eissn>1872-6844</eissn><coden>EPIRE8</coden><abstract>Summary To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance ( p = 0.01) and a shorter half-life ( p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>21282041</pmid><doi>10.1016/j.eplepsyres.2011.01.007</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-1211 |
| ispartof | Epilepsy research, 2011-03, Vol.94 (1), p.117-120 |
| issn | 0920-1211 1872-6844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_856775132 |
| source | ScienceDirect Journals |
| subjects | Adolescent Adult Aged Anticonvulsants - blood Anticonvulsants - pharmacokinetics Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Area Under Curve Biological and medical sciences Case-Control Studies Drug interaction Enzyme induction Enzyme Induction - drug effects Epilepsy Epilepsy - drug therapy Epilepsy - enzymology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Levetiracetam Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacokinetics Pharmacology. Drug treatments Piracetam - analogs & derivatives Piracetam - blood Piracetam - pharmacokinetics Piracetam - therapeutic use Time Factors Young Adult |
| title | Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T03%3A16%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20enzyme%20inducing%20antiepileptic%20drugs%20on%20the%20pharmacokinetics%20of%20levetiracetam%20in%20patients%20with%20epilepsy&rft.jtitle=Epilepsy%20research&rft.au=Freitas-Lima,%20Priscila&rft.date=2011-03-01&rft.volume=94&rft.issue=1&rft.spage=117&rft.epage=120&rft.pages=117-120&rft.issn=0920-1211&rft.eissn=1872-6844&rft.coden=EPIRE8&rft_id=info:doi/10.1016/j.eplepsyres.2011.01.007&rft_dat=%3Cproquest_cross%3E856775132%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c458t-838900523f1817782a82d1100c59e9ea3b92eddbc305e2aed20ee412420821323%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=856775132&rft_id=info:pmid/21282041&rfr_iscdi=true |