Protective role of endogenous melatonin in the early course of human acute pancreatitis

:  Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects. This study presents the first data on the dynamic changes of endogenous melatonin in the early phase of human AP. Morning (08:00 hr) serum melato...

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Published in:Journal of pineal research 2011-01, Vol.50 (1), p.71-77
Main Authors: Belyaev, Orlin, Herzog, Torsten, Munding, Johanna, Bolik, Bernd, Vosschulte, Andreas, Uhl, Waldemar, Müller, Christophe A.
Format: Article
Language:English
Subjects:
Acute Disease
acute pancreatitis
Adolescent
Adult
Aged
Aged, 80 and over
amylase
Anti-Inflammatory Agents - metabolism
Antioxidants - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunologic Factors - metabolism
Indexing in process
Male
melatonin
Melatonin - metabolism
Middle Aged
pancreas
Pancreatitis - metabolism
prognosis
severity
Young Adult
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Summary::  Melatonin plays a protective role in experimental acute pancreatitis (AP) because of its antioxidative, antiinflammatory, and immunomodulatory effects. This study presents the first data on the dynamic changes of endogenous melatonin in the early phase of human AP. Morning (08:00 hr) serum melatonin concentrations were measured by ELISA in 75 patients with AP for the first 5 days after the onset of pain. According to the Atlanta classification, 26 patients suffered a mild AP (MAP). The other 49 developed a severe AP (SAP). Median melatonin concentrations of healthy volunteers were used as a control. Median melatonin level in healthy controls was 18.5 pg/mL. Levels of melatonin were significantly higher in the first 24 hr after onset of disease in patients with MAP compared to those with SAP, 51.2 versus 8.7 pg/mL (P = 0.01). Melatonin values were the same in MAP and SAP during the remainder of the study period. Melatonin concentrations during the first 24 hr after the onset of pain in younger patients (35 yrs): 73 versus 8.7 pg/mL (P = 0.01). No correlation existed between melatonin levels and the following parameters: gender, etiology (biliary versus alcohol induced), and histological findings (edematous versus necrotizing versus infected necrosis). High endogenous melatonin serum levels in the first 24 hr after the onset of AP played a protective role and favoured a mild course of the disease in humans, especially in young patients.
ISSN:0742-3098
1600-079X
DOI:10.1111/j.1600-079X.2010.00811.x