Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: Involvement of estrogen receptors and oxidative stress

This study examined neuroprotective effect of silymarin (SM) in a model of Parkinson's disease (PD). Unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated i.p. with SM (100 and 200 mg/kg) 1 h before neurotoxin injection. Fulvestrant was used to evaluate the involveme...

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Bibliographic Details
Published in:Neuroscience letters 2010-08, Vol.480 (3), p.206-210
Main Authors: Baluchnejadmojarad, Tourandokht, Roghani, Mehrdad, Mafakheri, Mehdi
Format: Article
Language:English
Subjects:
6-Hydroxydopamine
Animals
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Estrogen receptor
Fundamental and applied biological sciences. Psychology
Male
Medical sciences
Neurology
Neuroprotective Agents - pharmacology
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
Parkinson's disease
Parkinsonian Disorders - drug therapy
Parkinsonian Disorders - metabolism
Parkinsonian Disorders - physiopathology
Rats
Rats, Wistar
Receptors, Estrogen - metabolism
Receptors, Estrogen - physiology
Silymarin
Silymarin - pharmacology
Vertebrates: nervous system and sense organs
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Summary:This study examined neuroprotective effect of silymarin (SM) in a model of Parkinson's disease (PD). Unilateral intrastriatal 6-hydroxydopamine (6-OHDA)-lesioned rats were pretreated i.p. with SM (100 and 200 mg/kg) 1 h before neurotoxin injection. Fulvestrant was used to evaluate the involvement of estrogen receptors. Net apomorphine-induced rotations and number of Nissl-stained neurons of substantia nigra pars compacta (SNC) were counted in addition to measurement of oxidative stress markers. SM administration only at a dose of 200 mg/kg attenuated the rotational behavior in 6-OHDA-lesioned rats and protected the neurons of SNC against its toxicity and fulvestrant partially attenuated this beneficial effect of SM. In addition, pretreatment with SM at a dose of 200 mg/kg significantly decreased the 6-OHDA-induced thiobarbituric acid reactive substances (TBARS) formation. SM exhibits a dose-dependent neuroprotective effect against 6-OHDA toxicity, partly through attenuating oxidative stress and via an estrogenic pathway.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2010.06.038