Effect of subchronic phencyclidine administration on sucrose preference and hippocampal parvalbumin immunoreactivity in the rat

Persistent blockade of NMDA receptor function by repeated phencyclidine dosing produces pathophysiological changes that model deficits observed in schizophrenia. The present study investigates the effects of subchronic phencyclidine administration (PCP; 2 or 5 mg/kg bi-daily for 7 days followed by a...

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Bibliographic Details
Published in:Neuroscience letters 2010-03, Vol.471 (3), p.144-147
Main Authors: Jenkins, Trisha A., Harte, Michael K., Reynolds, Gavin P.
Format: Article
Language:English
Subjects:
Affective Symptoms - psychology
Anhedonia
Animals
Biological and medical sciences
Choice Behavior
Disease Models, Animal
Dose-Response Relationship, Drug
Drinking
Drinking Behavior - drug effects
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Immunohistochemistry
Male
Neurons - drug effects
Neurons - metabolism
Parvalbumin
Parvalbumins - metabolism
Phencyclidine
Phencyclidine - administration & dosage
Pleasure
Rat
Rats
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Schizophrenia - metabolism
Schizophrenia - pathology
Schizophrenic Psychology
Sucrose
Taste
Vertebrates: nervous system and sense organs
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Summary:Persistent blockade of NMDA receptor function by repeated phencyclidine dosing produces pathophysiological changes that model deficits observed in schizophrenia. The present study investigates the effects of subchronic phencyclidine administration (PCP; 2 or 5 mg/kg bi-daily for 7 days followed by a drug-free period) on sucrose choice, a measure of anhedonia. Sucrose preference in a two-bottle sucrose–water choice test was assessed 1 and 2 weeks after PCP. Results showed no differences in sucrose intake between PCP rats and controls, nor a difference in water intake or total volume of liquid consumed at either time-point. Six weeks post-PCP, analysis of brains showed a reduction in expression of parvalbumin immunoreactive neurons in the hippocampus with significant reductions localised to the CA1 and CA2/3 regions. These results demonstrate that while subchronic PCP may not be a valid model for the negative symptom of anhedonia observed in schizophrenia, it induces pathology in the brain in hippocampal subregions that are reminiscent of changes observed in schizophrenia.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2010.01.028