Chemical studies on the roots of Uvaria welwitschii

A chemical investigation of the chloroform extract of the roots of Uvaria welwitschii (Annonaceae), an African traditional medicine taken for stomach ache, led to the isolation of eight new compounds, named welwitschins A–H ( 1 – 8 ), together with five known compounds ( 9 – 13 ). The structural elu...

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Bibliographic Details
Published in:Journal of natural medicines 2011-04, Vol.65 (2), p.313-321
Main Authors: Moriyasu, Masataka, Nakatani, Noriyoshi, Ichimaru, Momoyo, Nishiyama, Yumi, Kato, Atsushi, Mathenge, Simon G., Juma, Francis D., Chalo Mutiso, Patrick B.
Format: Article
Language:English
Subjects:
Annonaceae - chemistry
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Survival - drug effects
Chromatography, High Pressure Liquid
Complementary & Alternative Medicine
Flavonoids - chemistry
Flavonoids - pharmacology
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Molecular Structure
Original Paper
Pharmacology/Toxicology
Pharmacy
Plant Roots - chemistry
Plant Sciences
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Summary:A chemical investigation of the chloroform extract of the roots of Uvaria welwitschii (Annonaceae), an African traditional medicine taken for stomach ache, led to the isolation of eight new compounds, named welwitschins A–H ( 1 – 8 ), together with five known compounds ( 9 – 13 ). The structural elucidation by spectroscopic studies of the compounds isolated is described. All new compounds were flavonoids having a 2-hydroxy-3,4,6-trimethoxyphenyl moiety in the A-ring, and unsubstituted phenyl in the B-ring. Four of them ( 1 – 4 ) were monomeric flavonoids while the others ( 5 – 8 ) were dimeric flavonoids. The cytotoxicity of the isolated compounds against human promyelocytic leukemia HL-60 cells was investigated.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-010-0498-2