Histological description of the lymphadenopathy related to Toscana virus infection. Report of a case

Toscana virus (TOSV) infection is a frequent cause of meningitis in central Italy during summer. The disease generally has a benign course. Rarely, the infection produces a severe disease, with encephalitis and signs of systemic involvement, including lymphadenopathy. Since there is no clinical nece...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2011-03, Vol.207 (3), p.197-201
Main Authors: Ranaldi, Renzo, Goteri, Gaia, Biagetti, Simona, Cusi, Maria Grazia, Rossini, Simonetta
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antipyretics - therapeutic use
Biopsy
Histological features
Humans
Hyperplasia
Immunohistochemistry
Lymph Node Excision
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymph Nodes - virology
Lymphadenopathy
Lymphatic Diseases - drug therapy
Lymphatic Diseases - pathology
Lymphatic Diseases - virology
Male
Phlebotomus Fever - complications
Phlebotomus Fever - drug therapy
Phlebotomus Fever - virology
RNA, Viral - isolation & purification
Sandfly fever Naples virus - genetics
Sandfly fever Naples virus - pathogenicity
Toscana virus
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Summary:Toscana virus (TOSV) infection is a frequent cause of meningitis in central Italy during summer. The disease generally has a benign course. Rarely, the infection produces a severe disease, with encephalitis and signs of systemic involvement, including lymphadenopathy. Since there is no clinical necessity of performing lymph node biopsy in such cases, the histopathological feature of TOSV-related lymphadenitis is not known. We herein present a case in which lymphadenopathy preceded the onset of meningitis. The excised lymph node showed a non-specific mixed-type lymphoid hyperplasia, with follicular hyperplasia, sinusal expansion and paracortical involvement. We also demonstrated the presence of viral protein and viral RNA in the lymph node tissue.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2010.07.010