Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population

Two markers rs9652490 and rs11856808 both located in intron 3 of the LINGO1 gene have been nominated recently to be associated with essential tremor (ET). Although ET and Parkinson's disease (PD) are considered as different entities, they have many overlapping clinical and pathological features...

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Bibliographic Details
Published in:Neuroscience letters 2010-09, Vol.481 (2), p.69-72
Main Authors: Zuo, Xing, Jiang, Hong, Guo, Ji-feng, Yu, Ren-he, Sun, Qi-ying, Hu, Liang, Wang, Lei, Yao, Ling-yan, Shen, Lu, Pan, Qian, Yan, Xin-xiang, Xia, Kun, Tang, Bei-sha
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Essential tremor
Essential Tremor - genetics
Female
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Testing - methods
Genotype
Humans
LINGO1 gene
Male
Medical sciences
Membrane Proteins - genetics
Middle Aged
Nerve Tissue Proteins - genetics
Neurology
Parkinson Disease - genetics
Polymorphism
Polymorphism, Single Nucleotide - genetics
Sporadic Parkinson's disease
Vertebrates: nervous system and sense organs
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Summary:Two markers rs9652490 and rs11856808 both located in intron 3 of the LINGO1 gene have been nominated recently to be associated with essential tremor (ET). Although ET and Parkinson's disease (PD) are considered as different entities, they have many overlapping clinical and pathological features. We aimed to evaluate the role of rs9652490 and rs11856808 in the development of ET and PD. To this point, we sequenced the region involving the two markers in 109 ET cases, 425 sporadic Parkinson's disease (SPD) cases and 430 controls in Chinese population. After stratification by age, the rs9652490G allele suggested protective role in the early onset PD (EOPD, age at onset ≤50 years) group compared with age matched controls (OR = 0.56, 95% CI: 0.35–0.90, p = 0.015). No other significant association was found. We concluded that the two markers rs9652490 and rs11856808 were not strongly related to the development of ET or late onset SPD, but the rs9652490G allele might be a protective factor for EOPD in Chinese population.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2010.06.041