Dietary administration of nucleotides to enhance growth, humoral immune responses, and disease resistance of the rainbow trout ( Oncorhynchus mykiss) fingerlings

• Published in: Fish & shellfish immunology 2011, Vol.30 (1), p.189-193
• Main Authors: Tahmasebi-Kohyani, Ahmad, Keyvanshokooh, Saeed, Nematollahi, Amin, Mahmoudi, Nemat, Pasha-Zanoosi, Hossein
• Format: Article
• Language: English
• Subjects: Animal Feed - analysis; Animal Nutritional Physiological Phenomena; Animals; bacterial infections; blood serum; Diet - veterinary; Dietary nucleotides; Dietary Supplements; disease resistance; Dose-Response Relationship, Drug; experimental diets; feed conversion; fingerlings; fish diseases; Fish Diseases - immunology; Fish Diseases - prevention & control; Growth; growth performance; humoral immunity; immune response; Immunity; immunoglobulin M; lysozyme; Muramidase - metabolism; nucleotides; Nucleotides - pharmacology; Oncorhynchus mykiss; oral administration; Rainbow trout; Streptococcal Infections - immunology; Streptococcal Infections - prevention & control; Streptococcal Infections - veterinary; Streptococcus iniae
• ISSN: 1050-4648; 1095-9947
• DOI: 10.1016/j.fsi.2010.10.005

A feeding study was conducted to determine the effect of dietary nucleotides (NT) on growth performance, immune responses and resistance of rainbow trout fingerlings to Streptococcus iniae. A basal diet supplemented with 0 (control), 0.5, 1, 1.5 and 2 g NT kg −1 to formulate five experimental diets. Each diet was randomly allocated to triplicate groups of fish with initial average weight of approximately 23 g. After 8 weeks of feeding trial, fish fed diets with 1.5–2 g NT kg −1 had the highest final weight and SGR, followed by groups fed the diets with 0.5–1 g NT kg −1, and lowest in fish fed the NT-free control diet. The feed conversion ratio (FCR) was better when the fish were fed diet with 2 g NT kg −1. The ACH 50 level and lysozyme activity in serum were found to be significantly ( P