In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon. Dichloromethane and methanolic extracts of each plant were tested for the...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2011-02, Vol.133 (3), p.1103-1108
Main Authors: Lekana-Douki, Jean Bernard, Bongui, Jean Bernard, Oyegue Liabagui, Sandrine Lydie, Zang Edou, Sonya Estelle, Zatra, Rafika, Bisvigou, Ulrich, Druilhe, Pierre, Lebibi, Jacques, Toure Ndouo, Fousseyni Samba, Kombila, Maryvonne
Format: Article
Language:English
Subjects:
Antiplasmodial activity
Biological and medical sciences
Cell Survival - drug effects
Cytotoxicity
Dorstenia
Gabon
General pharmacology
Humans
Leonotis
Malaria - drug therapy
Medical sciences
Medicine, African Traditional
Myristica
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
Species Specificity
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Summary:As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon. Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on two chloroquine-resistant strains of Plasmodium falciparum (FCB and W2), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. The methanolic extract of Staudtia gabonensis and the dichloromethane extract of Adhatoda latibracteata showed high antiplasmodial activity (IC50
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2010.11.056