Comparison of Ca super(2+) Responses to Stimulation of Glutamate Receptors in the Rat Cerebral Cortex after Hypobaric Hypoxia of Different Severities

• Published in: Neuroscience and behavioral physiology 2010-11, Vol.40 (9), p.1012-1016
• Main Authors: Semenov, D G, Belyakov, A V, Samoilov, MO
• Format: Article
• Language: English
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-010-9361-x

Hypoxia modifies glutamatergic signaling in the brain, inducing prolonged increases in intracellular Ca super(2+) levels. Depending on the severity of the applied hypoxia, the level and temporospatial profile of Ca super(2+) accumulation during reoxygenation triggers fundamentally different Ca super(2+)-dependent reactions leading either to cell death or hypoxic tolerance. With the aim of identifying the specific characteristics of the involvement of different glutamate receptors in these alternative processes, the patterns of Ca super(2+) responses to stimulation of various subtypes of ionotropic and metabotropic glutamate receptors with their agonists were identified in slices of piriform cortex from rats subjected one day previously to severe (pathogenic) or moderate (adaptogenic) hypobaric hypoxia. Hypoxia of different modalities produced different modifications of the Ca super(2+) responses of all the receptors tested. The most marked differences were seen for Ca super(2+) responses to stimulation of group I metabotropic glutamate receptors.