Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes

Diabet. Med. 28, 450–454 (2011) Aim  In diabetes, endothelial dysfunction and an altered retinal blood flow have been reported and precede overt macrovascular and microvascular disease. Furthermore, an association between postprandial hyperglycaemia, retinopathy and cardiovascular disease has been o...

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Published in:Diabetic medicine 2011-04, Vol.28 (4), p.450-454
Main Authors: Chittari, M. V., McTernan, P., Bawazeer, N., Constantinides, K., Ciotola, M., O'Hare, J. P., Kumar, S., Ceriello, A.
Format: Article
Language:English
Subjects:
acute hyperglycaemia
Adult
Biological and medical sciences
Blood Flow Velocity
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Retinopathy - blood
Diabetic Retinopathy - physiopathology
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
endothelial function
Endothelium, Vascular - physiopathology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Glucose Tolerance Test
Humans
Hyperglycemia - blood
Hyperglycemia - physiopathology
Male
Medical sciences
Middle Aged
Regional Blood Flow
Retina
retinal vasoreactivity
Retinal Vessels - physiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Diabet. Med. 28, 450–454 (2011) Aim  In diabetes, endothelial dysfunction and an altered retinal blood flow have been reported and precede overt macrovascular and microvascular disease. Furthermore, an association between postprandial hyperglycaemia, retinopathy and cardiovascular disease has been observed. Methods  Endothelial function and retinal vascular reactivity have been measured in baseline conditions in 10 healthy control subjects and 21 patients with Type 2 diabetes. In the patients with Type 2 diabetes, endothelial function and retinal vascular reactivity have been also measured every hour, for 4 h, during an oral glucose tolerance test. Endothelial function has been evaluated by measuring flow‐mediated vasodilation of the brachial artery, while retinal vascular reactivity has been measured using a retinal vessel analyser, during a flicker. Results  At 1 and 2 h after glucose ingestion, endothelial function decreased (P 
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2010.03223.x