Trace elements status in diabetes mellitus type 2: Possible role of the interaction between molybdenum and copper in the progress of typical complications

Abstract It is well established that both, the deficiency and possible overload of mineral micronutrients have adverse health effects. It is also generally accepted that non-essential xenobiotics contribute to oxidative damage, which is considered one of the principal factors in diabetes and its com...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2011-03, Vol.91 (3), p.333-341
Main Authors: Flores, Crescencio Rodríguez, Puga, Mónica Preciado, Wrobel, Katarzyna, Garay Sevilla, Ma. Eugenia, Wrobel, Kazimierz
Format: Article
Language:English
Subjects:
Adult
Complications
Copper - analysis
Data Interpretation, Statistical
Diabetes Complications - etiology
Diabetes mellitus type 2
Diabetes Mellitus, Type 2 - complications
Disease Progression
Endocrinology & Metabolism
Female
Humans
Inductively coupled plasma-mass spectrometry
Male
Mass Spectrometry
Middle Aged
Molybdenum - analysis
Molybdenum - blood
Molybdenum - urine
Trace elements
Trace Elements - analysis
Trace Elements - blood
Trace Elements - urine
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Summary:Abstract It is well established that both, the deficiency and possible overload of mineral micronutrients have adverse health effects. It is also generally accepted that non-essential xenobiotics contribute to oxidative damage, which is considered one of the principal factors in diabetes and its complications. The purpose of this work was to gain an insight on the global role of metal/metalloids in the progress of diabetes mellitus type 2. In such approach, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, mercury, cadmium and lead were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in serum and urine of 76 diabetic patients (age 52 ± 8 years, 5–16 years of DM2, 52 subjects with slight-to-moderate complications and 24 with severe complications). A series of anthropometric and clinical parameters usually evaluated in the follow-up of patients were assessed by standard methods. Statistical analysis (unpaired t -test, analysis of correlation and principal component analysis) was then carried out in search of possible relationships existing among metals/metalloids and these parameters. The results obtained suggest that antagonistic interaction between molybdenum and copper might be involved in the progress of diabetes complications.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2010.12.014