Women with Cardiovascular Disease Have Increased Risk of Osteoporotic Fracture

• Published in: Calcified tissue international 2011, Vol.88 (1), p.9-15
• Main Authors: Chen, Jian Sheng, Hogan, Chris, Lyubomirsky, Greg, Sambrook, Philip N.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biochemistry; Biomedical and Life Sciences; Body Mass Index; Calcium - administration & dosage; Cardiovascular disease; Cardiovascular Diseases - complications; Cardiovascular Diseases - epidemiology; Case-Control Studies; Cell Biology; Dietary Supplements - utilization; Endocrinology; Estrogen Replacement Therapy - utilization; Female; Fractures; Humans; Life Sciences; Middle Aged; Orthopedics; Osteoporosis; Osteoporosis, Postmenopausal - complications; Osteoporosis, Postmenopausal - epidemiology; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - etiology; Risk Factors; Vitamin D - administration & dosage; Women
• ISSN: 0171-967X; 1432-0827
• DOI: 10.1007/s00223-010-9431-7

This study investigated whether women with cardiovascular disease (CVD) would have an increased risk of fractures as osteoporosis and CVD share many common risk factors. From February 2006 to January 2007, 17,033 women aged ≥50 years (mean 71.8, range 50–106) were recruited by 1,248 primary care practitioners and interviewed by trained nurses. For each woman, 10-year probability of a future major osteoporotic fracture was estimated using the World Health Organization Fracture Risk Assessment Tool (FRAX). The study showed that the 10-year probability of a major osteoporotic fracture was higher for 6,219 CVD women compared to 10,814 non-CVD women after adjustment for age, BMI, current smoking, and alcohol use (adjusted geometric means 14.3 and 13.8%, respectively; P