Association of low serum creatinine, abnormal lipid profile, gender, age and ethnicity with type 2 diabetes mellitus in Trinidad and Tobago

• Published in: Diabetes research and clinical practice 2011-03, Vol.91 (3), p.342-347
• Main Authors: Nayak, B. Shivananda, Butcher, Donna M, Bujhawan, Shivanna, Chang, Dominique, Chang, Simone, Cabral-Samaroo, Diane, Cadan, Sandhya, Buchoon, Vanessa, Budhram, Lystra, Boyce, Melissa, Teelucksingh, Surujpaul
• Format: Article
• Language: English
• Subjects: Adult; Age Factors; Creatinine - blood; Diabetes Mellitus, Type 2 - epidemiology; Diabetics; Endocrinology & Metabolism; Ethnic Groups; Female; Humans; Lipid profile; Lipids - blood; Low serum creatinine; Male; Middle Aged; Risk Factors; Sex Factors; Trinidad and Tobago - epidemiology; Young Adult
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2010.12.017

Abstract Objective To study the association of low serum creatinine, abnormal lipid profile and demographic variables with type 2 diabetic Trinidadian subjects. Methods Data were obtained from a cohort of 1122 diabetic and non-diabetic patients from clinics in Trinidad. Variables measured included demographics, HbA1c , serum creatinine, lipid profile values and diabetic status. Results The sample consisted of 476 males (61.6% diabetic) and 646 females (50.3% diabetic). Most patients (59.2%) were Indo-Trinidadian, 23.4% were Afro-Trinidadian and 13.5% were of ‘mixed’ and ‘other’ categories. The majority (55.1%) of the patients were diabetic and diabetics were older than non-diabetics ( p = 0.000). Abnormal lipid profile OR = 0.728, CI (0.532, 0.994), serum creatinine categories OR = 1.520, CI (1.317, 1.754), gender OR = 0.690, CI (0.533, 0.892) and age groups OR = 1.305, CI (1.185, 1.437) were useful predictors of type 2 diabetes. Ethnicity was not a useful predictor: OR = 1.007, CI (0.869, 1.168). Serum creatinine (mean) was found to be lower in diabetics aged 21–50 than in their non-diabetic counterparts. However, above 50 years old, the reverse was true. Serum creatinine means were higher in males than in females ( p = 0.000). Conclusion Abnormal lipid profile, gender, age and serum creatinine are associated with type 2 diabetes. While age and gender are non-modifiable risk factors, steps should be taken to monitor and control the serum creatinine and lipid profile values of diabetics and non-diabetics.