Clomipramine Treatment and Repeated Restraint Stress Alter Parameters of Oxidative Stress in Brain Regions of Male Rats

This study aimed to compare the effects of repeated restraint stress alone and the combination with clomipramine treatment on parameters of oxidative stress in cerebral cortex, striatum and hippocampus of male rats. Animals were divided into control and repeated restraint stress, and subdivided into...

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Bibliographic Details
Published in:Neurochemical research 2010-11, Vol.35 (11), p.1761-1770
Main Authors: de Souza Balk, Rodrigo, Bridi, Jessika Cristina, de Lima Portella, Rafael, Carvalho, Nelson Rodrigues, Dobrachinski, Fernando, da Silva, Michele Hinerasky, Amaral, Guilherme Pires, Dias, Glaecir Roseni Mundstock, de Vargas Barbosa, Nilda, Soares, Felix Alexandre Antunes
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - physiopathology
Catalase - metabolism
Cell Biology
Clomipramine - pharmacology
Lipid Peroxidation - drug effects
Male
Neurochemistry
Neurology
Neurosciences
Original Paper
Oxidative Stress - drug effects
Rats
Rats, Wistar
Restraint, Physical
Stress, Psychological - physiopathology
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:This study aimed to compare the effects of repeated restraint stress alone and the combination with clomipramine treatment on parameters of oxidative stress in cerebral cortex, striatum and hippocampus of male rats. Animals were divided into control and repeated restraint stress, and subdivided into treated or not with clomipramine. After 40 days of stress and 27 days of clomipramine treatment with 30 mg/kg, the repeated restraint stress alone reduced levels of Na + , K + -ATPase in all tissues studied. The combination of repeated restraint stress and clomipramine increased the lipid peroxidation, free radicals and CAT activity as well as decreased levels of NP-SH in the tissues studied. However, Na + , K + -ATPase level decreased in striatum and cerebral cortex and the SOD activity increased in hippocampus and striatum. Results indicated that clomipramine may have deleterious effects on the central nervous system especially when associated with repeated restraint stress and chronically administered in non therapeutic levels.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-010-0240-1