Neonatal rhesus monkey is a potential animal model for studying pathogenesis of EV71 infection

• Published in: Virology (New York, N.Y.) N.Y.), 2011-03, Vol.412 (1), p.91-100
• Main Authors: Liu, Longding, Zhao, Hongling, Zhang, Ying, Wang, Jingjing, Che, Yanchun, Dong, Chenghong, Zhang, Xuemei, Na, Ruixiong, Shi, Haijing, Jiang, Li, Wang, Lichun, Xie, Zhongping, Cui, Pingfang, Xiong, Xiangling, Liao, Yun, Zhao, Shudong, Gao, Jiahong, Tang, Donghong, Li, Qihan
• Format: Article
• Language: English
• Subjects: Animal model; Animals; Animals, Newborn; Disease Models, Animal; Enterovirus 71 (EV71); Enterovirus A, Human - pathogenicity; Enterovirus Infections - pathology; Enterovirus Infections - transmission; Enterovirus Infections - virology; Feces - virology; Hand–foot–mouth disease (HFMD); Humans; Infectious Disease; Macaca mulatta - virology; Neonatal rhesus monkey; Pathogenesis
• ISSN: 0042-6822; 1096-0341
• DOI: 10.1016/j.virol.2010.12.058

Abstract Data from limited autopsies of human patients demonstrate that pathological changes in EV71-infected fatal cases are principally characterized by clear inflammatory lesions in different parts of the CNS; nearly identical changes were found in murine, cynomolgus and rhesus monkey studies which provide evidence of using animal models to investigate the mechanisms of EV71 pathogenesis. Our work uses neonatal rhesus monkeys to investigate a possible model of EV71 pathogenesis and concludes that this model could be applied to provide objective indicators which include clinical manifestations, virus dynamic distribution and pathological changes for observation and evaluation in interpreting the complete process of EV71 infection. This induced systemic infection and other collected indicators in neonatal monkeys could be repeated; the transmission appears to involve infecting new monkeys by contact with feces of infected animals. All data presented suggest that the neonatal rhesus monkey model could shed light on EV71 infection process and pathogenesis.