The 5-HTTLPR polymorphism and eating disorders: A meta-analysis

Objective: Eating disorders are influenced by both environmental factors and genes. The 5‐HTTLPR polymorphism of serotonin transporter gene has been suggested as a good candidate. This meta‐analysis was undertaken: (1) to investigate the association between 5‐HTTLPR and eating disorders considered a...

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Bibliographic Details
Published in:The International journal of eating disorders 2011-04, Vol.44 (3), p.191-199
Main Authors: Calati, Raffaella, De Ronchi, Diana, Bellini, Maurizio, Serretti, Alessandro
Format: Article
Language:English
Subjects:
5-HTTLPR
Adult and adolescent clinical studies
Alleles
Anorexia nervosa
Biological and medical sciences
Bulimia
bulimia nervosa
Eating behavior disorders
Eating disorders
Feeding and Eating Disorders - genetics
Genes
Genetic Predisposition to Disease
Genotype
Humans
Medical sciences
Meta-analysis
Polymorphism
Polymorphism, Genetic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk factors
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
serotonin trans-porter
Studies
Systematic review
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Summary:Objective: Eating disorders are influenced by both environmental factors and genes. The 5‐HTTLPR polymorphism of serotonin transporter gene has been suggested as a good candidate. This meta‐analysis was undertaken: (1) to investigate the association between 5‐HTTLPR and eating disorders considered as a whole, including anorexia (AN), bulimia (BN), and binge eating disorder (BED); (2) to extend recently reported findings on the association between 5‐HTTLPR and AN‐BN. Method: PubMed, ISI, and PsycINFO databases were searched for studies published until October 2009. Fifteen studies have been included. Data were analyzed with the Cochrane Collaboration Review Manager Software. Quality of studies and publication bias were assessed. Results: An association between S allele and eating disorders, in particular AN, has been found. Discussion: To be carrier of the 5‐HTTLPR S allele seem to represent a risk factor for eating disorders, especially for AN. However, considering the reported high between‐study heterogeneity, future studies should focus on more homogeneous endophenotype. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:191–199)
ISSN:0276-3478
1098-108X
DOI:10.1002/eat.20811