Mitophagy: the latest problem for Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Park...

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Bibliographic Details
Published in:Trends in molecular medicine 2011-03, Vol.17 (3), p.158-165
Main Authors: Vives-Bauza, Cristofol, Przedborski, Serge
Format: Article
Language:English
Subjects:
Animals
Autophagy
Humans
Mitochondria - enzymology
Mitochondria - genetics
Mitochondria - metabolism
Parkinson Disease - enzymology
Parkinson Disease - genetics
Parkinson Disease - physiopathology
Pathology
Protein Kinases - genetics
Protein Kinases - metabolism
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
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Summary:Parkinson's disease (PD) is a common neurodegenerative disorder of unknown cause. Some familial forms of PD are provoked by mutations in the genes encoding for the PTEN (phosphatase and tensin homolog)-induced putative kinase-1 (PINK1) and Parkin. Mounting evidence indicates that PINK1 and Parkin might function in concert to modulate mitochondrial degradation, termed mitophagy. However, the molecular mechanisms by which PINK1/Parkin affect mitophagy are just beginning to be elucidated. Herein, we review the main advances in our understanding of the PINK1/Parkin pathway. Because of the phenotypic similarities among the different forms of PD, a better understanding of PINK1/Parkin biology might have far-reaching pathogenic and therapeutic implications for both the inherited and the sporadic forms of PD.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2010.11.002