Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response

In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe(3)O(4)...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2011-03, Vol.40 (12), p.3039-3046
Main Authors: Guo, Xi Ming, Guo, Bin, Zhang, Qingyuan, Sun, Xuemei
Format: Article
Language:English
Subjects:
Absorption
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Camptothecin - administration & dosage
Camptothecin - analogs & derivatives
Camptothecin - chemistry
Drug Carriers - chemistry
Ferrosoferric Oxide - chemistry
Hydrogen-Ion Concentration
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Particle Size
Polystyrenes - chemistry
Spectroscopy, Fourier Transform Infrared
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Summary:In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe(3)O(4) magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.
ISSN:1477-9226
1477-9234
DOI:10.1039/c0dt01455a