Absorption of 10-hydroxycamptothecin on Fe3O4 magnetite nanoparticles with layer-by-layer self-assembly and drug release response

• Published in: Dalton transactions : an international journal of inorganic chemistry 2011-03, Vol.40 (12), p.3039-3046
• Main Authors: Guo, Xi Ming, Guo, Bin, Zhang, Qingyuan, Sun, Xuemei
• Format: Article
• Language: English
• Subjects: Absorption; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - chemistry; Camptothecin - administration & dosage; Camptothecin - analogs & derivatives; Camptothecin - chemistry; Drug Carriers - chemistry; Ferrosoferric Oxide - chemistry; Hydrogen-Ion Concentration; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Particle Size; Polystyrenes - chemistry; Spectroscopy, Fourier Transform Infrared
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/c0dt01455a

In this paper, the structural and zeta potential properties of 10-hydroxycamptothecin (HCPT) were investigated by FT-IR and zeta potential analyzer under different pH. The anticancer drug HCPT as a model drug was used to prepare a high-performance and relatively easy-to-fabricate system on Fe(3)O(4) magnetite nanoparticles by using a polystyrene sulfonate (PSS) and HCPT interlayer self-assembly method. The results obtained from FT-IR and XRD confirmed that HCPT was molecularly dispersed into the nanoparticles. The method holds not only environment-friendly characteristics and the ability to mimic the self-organization process in biological systems but also greatly decreases adjuvant polymers. In addition, the system has an ideal drug payload for the delivery of insoluble HCPTs.