Chaotically Accelerated Polymerase Chain Reaction by Microscale Rayleigh-Bénard Convection

Going with the flow: DNA replication by the polymerase chain reaction (PCR) can proceed at a greatly accelerated rate when performed in the presence of a chaotic flow induced by microscale thermal convection (see picture). The consequences of these effects sharply contradict established design rules...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-03, Vol.50 (13), p.3048-3052
Main Authors: Muddu, Radha, Hassan, Yassin A., Ugaz, Victor M.
Format: Article
Language:English
Subjects:
analytical methods
biochemistry
chaos
Computational Biology
Computer Simulation
DNA - chemistry
DNA - genetics
DNA Replication
microreactors
Nucleic Acid Denaturation
Polymerase Chain Reaction
Temperature
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Summary:Going with the flow: DNA replication by the polymerase chain reaction (PCR) can proceed at a greatly accelerated rate when performed in the presence of a chaotic flow induced by microscale thermal convection (see picture). The consequences of these effects sharply contradict established design rules for chemistry involving coupled flow and reaction.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201004217