Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging

We report that the ability of disodium 5'-deoxy-5'-thioguanosine-5'-monophosphate, Na(2)(5'-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5'-monophosphate, Na(2)(5'-GMP)...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (13), p.3882-3884
Main Authors: Kwan, Irene C M, Delley, Richard J, Hodgson, David R W, Wu, Gang
Format: Article
Language:English
Subjects:
Cations
Cations - chemistry
Chemical communication
G-Quadruplexes
Guanosine - analogs & derivatives
Guanosine Monophosphate - chemistry
Nucleotides
pH effects
Self-assembly
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Summary:We report that the ability of disodium 5'-deoxy-5'-thioguanosine-5'-monophosphate, Na(2)(5'-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5'-monophosphate, Na(2)(5'-GMP), which supports our earlier hypothesis regarding the importance of cation bridging.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc05654e