Side Differences of Carotid Intima-Media Thickness in Predicting Cardiovascular Events Among Patients With Coronary Artery Disease

Population-based studies have demonstrated differences in intima—media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between the left and...

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Bibliographic Details
Published in:Angiology 2011-04, Vol.62 (3), p.231-236
Main Authors: Lee, Stephen Wai-luen, Siu Han Hai, Jo Jo, Kong, Shun-ling, Lam, Yui-ming, Lam, Simon, Chan, Pak-hei, Chan, Ki-wan, Wong, Ka-lam, Tam, Chor-cheung, Chan, Raymond Hon-wah
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - pathology
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - pathology
Coronary heart disease
Disease-Free Survival
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Follow-Up Studies
Heart
Humans
Male
Medical sciences
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Tunica Intima - diagnostic imaging
Tunica Intima - pathology
Tunica Media - diagnostic imaging
Tunica Media - pathology
Ultrasonography
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Summary:Population-based studies have demonstrated differences in intima—media thickness (IMT) measured from the left and right common carotid arteries (CCAs). However, its prognostic implications among patients with established coronary artery disease (CAD) remain unknown. Correlations between the left and right CCAs and the composite end point of cardiac death or nonfatal acute coronary syndrome among 149 patients with angiographically confirmed stable CAD were studied. A total of 22 patients had cardiovascular events during the 32.1 ± 10.9 months follow-up. Multivariate analysis revealed that prior ischemic stroke (hazard ratio [HR]: 15.36, 95% confidence interval [CI]: 4.49-52.59, P < .001), extent of CAD (HR: 1.56, 95%CI: 1.01-2.42, P = .046), and right CCA IMT (HR: 17.07, 95%CI: 2.16-134.69, P = .007) but not the left CCA IMT, independently predicted cardiovascular events. The right CCA IMT independently predicted event-free survival among patients with established CAD, suggesting that the left and right CCA may exhibit different prognostic values in our population.
ISSN:0003-3197
1940-1574
DOI:10.1177/0003319710379109