Aminoheterocycles as synthons for combinatorial Biginelli reactions

Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinator...

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Bibliographic Details
Published in:Molecular diversity 2011-02, Vol.15 (1), p.189-195
Main Authors: Ryabukhin, Sergey V, Plaskon, Andrey S, Boron, Sergey Yu, Volochnyuk, Dmitriy M, Tolmachev, Andrey A
Format: Article
Language:English
Subjects:
Aminoheterocycles
Biginelli reaction
Biochemistry
Biomedical and Life Sciences
Chemical reactions
Chlorotrimethylsilane
Combinatorial
Combinatorial Chemistry Techniques - methods
Combinatorics
Cyclization
Dihydropyrimidines
Full Length Paper
Heterocyclic Compounds - chemistry
Library
Life Sciences
MCR
Multicomponent reaction
Organic Chemistry
Pharmacy
Polymer Sciences
Small Molecule Libraries - chemical synthesis
Small Molecule Libraries - chemistry
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Summary:Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-010-9253-6