The Expression of Both Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 in Tissues Is Associated with Poor Prognosis in Colorectal Cancer Patients

• Published in: Digestive diseases and sciences 2011-04, Vol.56 (4), p.1194-1200
• Main Authors: Yoshinaga, Masahiro, Taki, Kentaro, Somada, Shinichi, Sakiyama, Yumiko, Kubo, Norihiko, Kaku, Toyoma, Tsuruta, Satoru, Kusumoto, Tetsuya, Sakai, Hironori, Nakamura, Kazuhiko, Takayanagi, Ryoichi, Muto, Yoichi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biochemistry; Biological and medical sciences; Cancer patients; Carcinoma - metabolism; Carcinoma - secondary; Colorectal cancer; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Cyclooxygenase 2 - biosynthesis; Development and progression; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Liver; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical research; Medical sciences; Medicine; Medicine & Public Health; Medicine, Experimental; Metastasis; Middle Aged; Oncology; Original Article; PPAR delta - biosynthesis; Prognosis; Receptors, CXCR4 - biosynthesis; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Transplant Surgery; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - biosynthesis; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-010-1389-9

Background The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (−)/COX-2 (+), PPAR δ (+)/COX-2 (−), and PPAR δ (−)/COX-2 (−) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis ( p