CTSS activation coexists with CD40 activation in human atheroma: Evidence from plasma mRNA analysis

By the analysis of plasma mRNA levels, we tested the hypothesis that, in human atheroma, CTSS activation coexists with activation of CD40. mRNAs were isolated from plasma of patients with coronary atherosclerosis and quantified by real-time RT–PCR. CTSS mRNA levels correlated with CD40 mRNA levels,...

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Published in:Clinical biochemistry 2011-04, Vol.44 (5), p.438-440
Main Authors: Cerne, Darko, Stern, Irma, Marc, Janja, Cerne, Andreja, Zorman, Darko, Krzisnik-Zorman, Simona, Kranjec, Igor
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cathepsins - genetics
Cathepsins - metabolism
CD40
CD40 Antigens - metabolism
Coronary atherosclerosis
Coronary heart disease
CTSS
Female
Heart
Humans
Male
Medical sciences
Middle Aged
mRNA
Plaque, Atherosclerotic - metabolism
Plasma
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
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Summary:By the analysis of plasma mRNA levels, we tested the hypothesis that, in human atheroma, CTSS activation coexists with activation of CD40. mRNAs were isolated from plasma of patients with coronary atherosclerosis and quantified by real-time RT–PCR. CTSS mRNA levels correlated with CD40 mRNA levels, independently of observed traditional risk factors for atherosclerosis and pharmacological treatment. Our results suggest that CTSS mediated atherogenesis may be associated with a CD40 mediated inflammatory and immune response. Further invasive atheroma analysis is reasonable.
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2011.01.003