The pattern of cortical atrophy in patients with Parkinson's disease according to cognitive status

Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (G...

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Bibliographic Details
Published in:Movement disorders 2011-02, Vol.26 (2), p.289-296
Main Authors: Song, Sook K., Lee, Ji E., Park, Hae-Jeong, Sohn, Young H., Lee, Jong Doo, Lee, Phil Hyu
Format: Article
Language:English
Subjects:
Atrophy - pathology
Atrophy - psychology
Biological and medical sciences
Cerebral Cortex - pathology
Cognition - physiology
cortical atrophy
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
dementia
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical sciences
mild cognitive impairment
Nerve Fibers, Unmyelinated - pathology
Neurology
Neurons - pathology
Neuropsychological Tests
Parkinson Disease - pathology
Parkinson Disease - psychology
Parkinson's disease
Prospective Studies
Statistics, Nonparametric
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Summary:Background: Cognitive dysfunction is common in Parkinson's disease (PD), and along with PD with dementia (PDD), the concept of mild cognitive impairment in PD (PD‐MCI) has been introduced. Methods: To identify structural candidates according to cognitive status in PD, we compared gray matter (GM) density across PD‐intact cognition (PD‐IC, n = 23), PD‐MCI (n = 27), and PDD (n = 18) using voxel‐based morphometry. Results: The demographic data among PD subjects were similar, however, general cognition and disease duration were more severe in PD‐MCI and PDD than in PD‐IC. Compared with controls, GM density was significantly decreased in the left occipital area in PD‐IC; the bilateral temporal, left prefrontal and insular, and right occipital areas in PD‐MCI; and in widespread brain areas in PDD. Compared with PD‐IC, patients with PD‐MCI had significantly decreased GM density in the right middle frontal area, and those with PDD had decreased GM density in the right parietal, middle frontal, insular, and lentiform areas. GM density in patients with PDD was significantly decreased in the bilateral middle temporal, right inferior temporal, and left middle and superior prefrontal areas. PDD patients with shorter disease duration before dementia (
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.23477