Effects of curcumin on the dorsal root ganglion structure and functional recovery after sciatic nerve crush in rat

• Published in: Micron (Oxford, England : 1993) England : 1993), 2011-07, Vol.42 (5), p.449-455
• Main Authors: Noorafshan, Ali, Omidi, Ameneh, Karbalay-Doust, Saeid, Aliabadi, Elham, Dehghani, Farzaneh
• Format: Article
• Language: English
• Subjects: Administration, Oral; Animals; Central nervous system; Curcumin; Curcumin - administration & dosage; Dorsal root ganglion; Female; ganglia; Ganglia, Spinal - cytology; Ganglia, Spinal - drug effects; Ganglia, Spinal - physiology; nerve tissue; Neuroprotective Agents - administration & dosage; neuroprotective effect; Peripheral nerve injury; Rats; Rats, Sprague-Dawley; Sciatic Nerve - drug effects; Sciatic Nerve - injuries; Sciatic Nerve - physiology; Stereology; surface area
• ISSN: 0968-4328; 1878-4291
• DOI: 10.1016/j.micron.2011.01.002

► Sciatic function index and dorsal root ganglion cells were evaluated after sciatic nerve crush. ► Volume and surface of A- and B-cells reduced after crush. ► Number of A-, B- and satellite cells reduced after crush. ► Curcumin promotes the functional recovery of the nerve. ► Curcumin has a neuroprotective effect on the dorsal root ganglion cells. Curcumin has protective effects on a variety of CNS injury models. Our purpose was to assess the effects of curcumin on the dorsal root ganglion (DRG) and functional recovery in sciatic nerve crush (SNC) of rats. The fifth lumbar DRG was removed 28 days after SNC. Sciatic functional index (SFI) and also the DRG structure were evaluated, using stereological methods to assess the effects of curcumin. The volume and number of A- and B-cells were reduced in the SNC as compared with the sham-operated animals. In curcumin treated rats, the volume decreased but in a lesser extent and it was ∼10% and ∼15% higher on the average in comparison with the non-treated SNC (P