Enantio- and Regioselective Iridium-Catalyzed Allylic Hydroxylation

The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2011-02, Vol.133 (7), p.2072-2075
Main Authors: Gärtner, Martin, Mader, Steffen, Seehafer, Kai, Helmchen, Günter
Format: Article
Language:English
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Summary:The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with a representative set of substrates.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja109953v