Intestinal type adenocarcinoma of the ethmoid sinus in wood and leather workers: A retrospective study of 153 cases

Background The purpose of our study was to identify the role of work exposure to organic dusts in patients with malignant paranasal sinus tumors. Methods We analyzed all patients surgically treated for a malignant paranasal sinus tumor at our institution between 1987 and 2006. All patients were spec...

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Published in:Head & neck 2011-04, Vol.33 (4), p.535-542
Main Authors: Cantu, Giulio, Solero, Carlo L., Mariani, Luigi, Lo Vullo, Salvatore, Riccio, Stefano, Colombo, Sarah, Pompilio, Madia, Perrone, Federica, Formillo, Paolo, Quattrone, Pasquale
Format: Article
Language:English
Subjects:
Adenocarcinoma - etiology
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Biological and medical sciences
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
craniofacial resection
Dust
Ethmoid Sinus
Female
Humans
intestinal-type adenocarcinoma
Male
Maxillary Sinus
Medical sciences
Middle Aged
Neoplasm Recurrence, Local
Occupational Diseases - etiology
Occupational Diseases - mortality
Occupational Diseases - pathology
occupational tumors
Otorhinolaryngology. Stomatology
Paranasal Sinus Neoplasms - etiology
Paranasal Sinus Neoplasms - mortality
Paranasal Sinus Neoplasms - pathology
paranasal sinuses
Survival Analysis
Wood
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Summary:Background The purpose of our study was to identify the role of work exposure to organic dusts in patients with malignant paranasal sinus tumors. Methods We analyzed all patients surgically treated for a malignant paranasal sinus tumor at our institution between 1987 and 2006. All patients were specifically asked about their occupational history. The tumor site was classified as maxillary or ethmoid sinus. Adenocarcinomas were divided into intestinal type (ITAC) and non‐ITAC. Results The sample included 345 patients with ethmoid sinus and 301 maxillary sinus. Regarding the ethmoid sinus, we found an exposure to organic dusts in 148 of 153 patients with ITAC, in 3 of 16 patients with non‐ITAC adenocarcinoma, and in 10 of 176 patients with other tumors. Regarding the maxillary sinus, we found an exposure in 1 of 20 patients with non‐ITAC adenocarcinoma and in 4 of 281 patients with other histologies. Conclusion Our study demonstrates that only ethmoid ITACs have an indisputable relationship with the exposure to organic dusts. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21485