Recent developments in natural product synthesis using metal-catalysed C-H bond functionalisation

Metal-catalysed C-H bond functionalisation has had a significant impact on how chemists make molecules. Translating the methodological developments to their use in the assembly of complex natural products is an important challenge for the continued advancement of chemical synthesis. In this tutorial...

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Bibliographic Details
Published in:Chemical Society reviews 2011-04, Vol.40 (4), p.1885-1898
Main Authors: McMurray, Lindsay, O'Hara, Fionn, Gaunt, Matthew J
Format: Article
Language:English
Subjects:
Biological Products - chemical synthesis
Biological Products - chemistry
Carbon - chemistry
Catalysis
Hydrogen - chemistry
Metals - chemistry
Oxidation-Reduction
Stereoisomerism
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Summary:Metal-catalysed C-H bond functionalisation has had a significant impact on how chemists make molecules. Translating the methodological developments to their use in the assembly of complex natural products is an important challenge for the continued advancement of chemical synthesis. In this tutorial review, we describe selected recent examples of how the metal-catalysed C-H bond functionalisation has been able to positively affect the synthesis of natural products.
ISSN:0306-0012
1460-4744
DOI:10.1039/c1cs15013h