A rare case of oral epithelioid sarcoma of the gingiva

Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor. ES can be classified into proximal, distal, and fibroma-like subtypes. These tumors show both mesenchymal and epithelial immunophenotypes. Microscopically, the proximal type ES is usually characterized by nodules of spindle and epitheli...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2011-04, Vol.111 (4), p.e25-e28
Main Authors: Hagström, Jaana, DDS, PhD, Mesimäki, Karri, MD, DDS, PhD, Apajalahti, Satu, DDS, PhD, Haglund, Caj, MD, PhD, Rönty, Mikko, MD, PhD, Sarlomo-Rikala, Maarit, MD, PhD
Format: Article
Language:English
Subjects:
12E7 Antigen
Adult
Antigens, CD - analysis
Cell Adhesion Molecules - analysis
Dentistry
Desmin - analysis
Diagnosis, Differential
Gingival Neoplasms - chemistry
Gingival Neoplasms - pathology
Gingival Neoplasms - surgery
Humans
Keratins - analysis
Male
Mandible
Sarcoma - chemistry
Sarcoma - pathology
Sarcoma - surgery
Surgery
Vimentin - analysis
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Description
Summary:Epithelioid sarcoma (ES) is a rare malignant soft tissue tumor. ES can be classified into proximal, distal, and fibroma-like subtypes. These tumors show both mesenchymal and epithelial immunophenotypes. Microscopically, the proximal type ES is usually characterized by nodules of spindle and epithelioid cells growing in granuloma-like pattern often presenting with central necrosis. Immunohistochemically these tumors are vimentin, pancytokeratin, and usually EMA (80%) positive. CD34 (50%) and CD99 (25%) may be positive, and occasionally SMA and S-100 immunopositivity has been reported. No specific genetic alterations have been found in ES. As far as we know, this is the first case in the literature to present ES in gingival mucosa.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2010.12.014