Solid State Mutarotation of Glucose

It has been recently shown that mechanical milling can amorphize d-glucose without any mutarotation, giving rise to an anomerically pure amorphous sample. We have taken advantage of this exceptional possibility to study the kinetic of mutarotation in the amorphous solid state. The investigations hav...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2011-02, Vol.115 (7), p.1698-1705
Main Authors: Dujardin, N, Dudognon, E, Willart, J.-F, Hédoux, A, Guinet, Y, Paccou, L, Descamps, M
Format: Article
Language:English
Subjects:
B: Biophysical Chemistry
Glucose - chemistry
Kinetics
Spectrum Analysis, Raman
Temperature
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Summary:It has been recently shown that mechanical milling can amorphize d-glucose without any mutarotation, giving rise to an anomerically pure amorphous sample. We have taken advantage of this exceptional possibility to study the kinetic of mutarotation in the amorphous solid state. The investigations have been performed in situ by time-resolved Raman spectroscopy. The results reveal an unexpected coupling between the mutarotation process and the structural relaxations involved in the glassy state.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp109382j