Short-term estrogen replacement therapy reduces platelet marker levels in Malaysian postmenopausal women

Objectives In healthy postmenopausal women (PMW) increased platelet activation has been associated with adverse cardiovascular events. There is much debate about the relationship between platelet function and serum estradiol level in PMW. This study assessed the effect of short-term oral estrogen re...

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Bibliographic Details
Published in:Menopause international 2011-03, Vol.17 (1), p.6-10
Main Authors: Sheikh, Shabbir Ahmad, Roshan, Tariq Mahmood, Khattak, Muhammad Naeem, Baig, Atif Amin, Noor, Shahreza Johan, Hassan, Rosline, Zaki, Nik Mohamed
Format: Article
Language:English
Subjects:
Blood Platelets - drug effects
Body Mass Index
Estradiol - pharmacology
Estrogen Replacement Therapy - methods
Female
Flow Cytometry
Humans
Malaysia
Middle Aged
P-Selectin - blood
P-Selectin - drug effects
Platelet Activation
Postmenopause - blood
Postmenopause - drug effects
Progesterone Congeners - pharmacology
Prospective Studies
Treatment Outcome
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Summary:Objectives In healthy postmenopausal women (PMW) increased platelet activation has been associated with adverse cardiovascular events. There is much debate about the relationship between platelet function and serum estradiol level in PMW. This study assessed the effect of short-term oral estrogen replacement therapy (ERT) on platelet activation markers (CD62P and PAC-1) and its correlation with age and body mass index (BMI) among healthy PMW. Methods A prospective intervention study was conducted at Hospital University Sains Malaysia, involving 48 healthy PMW who were evaluated for platelet activation marker levels as determined by flow cytometry, before and after two weeks of oral ERT with 0.625 mg of conjugated equine estrogen once daily. The pre- and post-ERT platelets activation markers difference was analysed by paired t-test. Results The pre-ERT, mean ± SD percentage levels of CD62P and PAC-1 were significantly reduced from 7.00 ± 5.91 and 41.75 ± 26.85 to 3.05 ± 2.47 and 20.86 ± 19.02, respectively, after two weeks of ERT (P value < 0.001). The correlation of platelet activation markers was significant with estradiol but not with age and BMI. Conclusion Short-term ERT leads to reduction in platelet activity, which might contribute to protection against cardiovascular diseases in healthy PMW.
ISSN:1754-0453
1754-0461
DOI:10.1258/mi.2011.011001