Influence of deltamethrin on nonspecific cellular and humoral defense mechanisms in rainbow trout (Oncorhynchus mykiss)

The influence of deltamethrin on the innate immunity in rainbow trout was examined. Fish were immersed in deltamethrin at doses of 1, 2, and 4 µg/L for 30 min. The results showed that deltamethrin at doses of 2 and 4 µg/L decreased phagocytic activity of spleen macrophages and proliferative response...

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Bibliographic Details
Published in:Environmental toxicology and chemistry 2010-03, Vol.29 (3), p.489-491
Main Authors: Siwicki, Andrzej K., Terech-Majewska, Elzbieta, Grudniewska, Joanna, Malaczewska, Joanna, Kazun, Krzysztof, Lepa, Agnieszka
Format: Article
Language:English
Subjects:
Animals
Chemical compounds
Deltamethrin
Dose-Response Relationship, Drug
Fish
Immersion
Immunity, Innate - drug effects
Immunoglobulins
Innate immunity
Insecticides - toxicity
Lymphocyte Activation - drug effects
Lymphocytes
Macrophages
Macrophages - drug effects
Macrophages - immunology
Nitriles - toxicity
Oncorhynchus mykiss
Oncorhynchus mykiss - immunology
Proteins
Pyrethrins - toxicity
Rainbow trout
Salmon
Serums
Toxicology
Trout
Water Pollutants, Chemical - toxicity
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Summary:The influence of deltamethrin on the innate immunity in rainbow trout was examined. Fish were immersed in deltamethrin at doses of 1, 2, and 4 µg/L for 30 min. The results showed that deltamethrin at doses of 2 and 4 µg/L decreased phagocytic activity of spleen macrophages and proliferative response of pronephros lymphocytes at days 1, 2, and 5 after immersion. Deltamethrin at these doses decreased the lysozyme activity, total protein, and immunoglobulin levels in serum. The greatest immunosuppressive influence of deltamethrin at dose 4 µg/L was observed at the end of the study. Environ. Toxicol. Chem. 2010;29:489–491. © 2009 SETAC
ISSN:0730-7268
1552-8618
1552-8618
DOI:10.1002/etc.75