Possible role of nitric oxide in newborns weight gain disorder caused by prolonged dexamethasone therapy (experimental study)

Experimental studies on rats revealed that the newborns growth retardation, caused by long-term treatment with Dexamethasone in the neonatal period, can be prevented by the simultaneous with dexamethasone administration of the nitric oxide donor--L-arginine. This indicates that the mentioned Dexamet...

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Bibliographic Details
Published in:Georgian medical news 2011-02 (191), p.49-53
Main Authors: Sinauridze, O D, Gongadze, N V, Kvachadze, I D, Bekaia, G L
Format: Article
Language:Russian
Subjects:
Animals
Arginine - administration & dosage
Dexamethasone - administration & dosage
Dexamethasone - adverse effects
Female
Male
Nitric Oxide - metabolism
Nitric Oxide Donors - administration & dosage
Nitric Oxide Synthase - antagonists & inhibitors
Rats
Weight Gain - drug effects
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Summary:Experimental studies on rats revealed that the newborns growth retardation, caused by long-term treatment with Dexamethasone in the neonatal period, can be prevented by the simultaneous with dexamethasone administration of the nitric oxide donor--L-arginine. This indicates that the mentioned Dexamethasone-induced growth disorder is caused by inhibition of Nitric Oxide Synthases activity.
ISSN:1512-0112