Molecular Recognition Force Spectroscopy Study of the Specific Lectin and Carbohydrate Interaction in a Living Cell

Molecular recognition force spectroscopy is used to study the specific interaction between RCA120 and Gal on living HeLa cells at the single‐molecule level (see picture). The results indicate that this technique can be used to explore the force and dynamics of lectin–carbohydrate interaction in livi...

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Bibliographic Details
Published in:Chemphyschem 2011-04, Vol.12 (5), p.909-912
Main Authors: Li, Yongjun, Wang, Jine, Xing, Chunyan, Wang, Zhenxin, Wang, Hongda, Zhang, Bailin, Tang, Jilin
Format: Article
Language:English
Subjects:
atomic force microscopy
Biological and medical sciences
carbohydrates
Cell interactions, adhesion
cell recognition
fluorescence microscopy
Fundamental and applied biological sciences. Psychology
Galactose - chemistry
HeLa Cells
Humans
Microscopy, Atomic Force
Microscopy, Fluorescence
Molecular and cellular biology
Plant Lectins - chemistry
Polyethylene Glycols - chemistry
proteins
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Summary:Molecular recognition force spectroscopy is used to study the specific interaction between RCA120 and Gal on living HeLa cells at the single‐molecule level (see picture). The results indicate that this technique can be used to explore the force and dynamics of lectin–carbohydrate interaction in living cells in their native environments.
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.201001008