Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study

Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = ...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2011-04, Vol.30 (2), p.188-193
Main Authors: Mani Tiwari, Amit Kumar, Mahdi, Abbas Ali, Chandyan, Sudarshna, Zahra, Fatima, Godbole, Madan Mohan, Jaiswar, Shyam Pyari, Srivastava, Vinod Kumar, Singh Negi, Mahendra Pal
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
adverse effects
Analysis of Variance
Anemia
Anemia, Iron-Deficiency - therapy
Anemias. Hemoglobinopathies
Antioxidant
antioxidant activity
antioxidants
Antioxidants - analysis
Biological and medical sciences
blood
cane sugar
Dietary Supplements
Diseases of red blood cells
Feeding. Feeding behavior
Female
ferrous sulfate
folic acid
Folic Acid - administration & dosage
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
glutathione
Glutathione - blood
glutathione peroxidase
glutathione-disulfide reductase
Hematinics - administration & dosage
Hematologic and hematopoietic diseases
hemoglobin
Humans
iron
Iron deficiency
Iron supplementation
Iron, Dietary - administration & dosage
lipids
Medical sciences
Nutritional deficiency
Oxidant
Oxidative Stress
peroxides
Prospective Studies
superoxide dismutase
Superoxide Dismutase - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
vitamin A
women
Young Adult
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Summary:Summary Background & aims This study was aimed to assess the desirable and undesirable effects of iron (100 mg/day as ferrous sulphate) and folic acid (500 μg/day) supplementation in iron deficient anemic women. Methods Iron and folic acid supplementations were given to 117 anemic women (mild = 55, moderate = 40, and severe = 22) and 60 age matched placebo treated (100 mg cane sugar) non-anemic controls for 100 days. Blood index values, oxidative stress parameters, antioxidant enzymes and vitamins were estimated as per standard protocols. Results Haemoglobin (Hb) levels along with antioxidant enzymes, namely catalase, superoxide dismutase (SOD), glutathione reductase (GSH-Rd), reduced glutathione (GSH) and total antioxidant capacity (TAC) were found significantly increased ( P  
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2010.08.001