A novel genetic risk factor for venous thrombosis

[...] it is fairly easy to "improve" on the wild-type sequence as a substrate for poly(A) polymerase. [...] changes increase thrombin generation in vitro, probably by changing the ratio between the procoagulant prothrombin and the anticoagulant proteins antithrombin and protein S. Furtherm...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2011-04, Vol.57 (4), p.637-638
Main Authors: Bertina, Rogier M, Vos, Hans L
Format: Article
Language:English
Subjects:
Anticoagulants
Disease
Humans
Inactivation
Mutation
Plasma
Proteins
Risk Factors
Studies
Thromboembolism
Venous Thrombosis - genetics
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Summary:[...] it is fairly easy to "improve" on the wild-type sequence as a substrate for poly(A) polymerase. [...] changes increase thrombin generation in vitro, probably by changing the ratio between the procoagulant prothrombin and the anticoagulant proteins antithrombin and protein S. Furthermore, they probably increase activated protein C resistance, owing to the inhibitory effects of prothrombin on the inactivation of factor Va by activated protein C (7 ).
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2010.158998