Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy

We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhib...

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Bibliographic Details
Published in:Antiviral therapy 2011-01, Vol.16 (2), p.253-256
Main Authors: YOUNG, Benjamin, FRANSEN, Signe, GREENBERG, Kenneth S, THOMAS, Amy, MARTENS, Sharon, ST CLAIR, Marty, PETROPOULOS, Christos J, HA, Belinda
Format: Article
Language:English
Subjects:
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Drug Resistance, Multiple, Viral - genetics
Genotype
HIV Infections - drug therapy
HIV Infections - transmission
HIV Infections - virology
HIV Integrase Inhibitors - pharmacology
HIV Protease Inhibitors - pharmacology
HIV-1 - drug effects
HIV-1 - genetics
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Microbial Sensitivity Tests
Middle Aged
Mutation
Pharmacology. Drug treatments
Pyrrolidinones - pharmacology
Raltegravir Potassium
Reverse Transcriptase Inhibitors - pharmacology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhibitor resistance mutations. This case illustrates an emerging need to consider the possibility of acquired INI resistance among newly diagnosed treatment-naive individuals harbouring multidrug-resistant HIV-1.
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP1748