Extraskeletal Ewing’s sarcoma in a 67-year-old man

Ewing’s sarcoma is a round-cell tumor that commonly arises from bone, but extraskeletal Ewing’s sarcoma (EES) uncommonly occurs in the deep soft tissue of the extremities or paravertebral region [1], and is morphologically indistinguishable from bone lesions. EES is generally found in adolescents an...

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Bibliographic Details
Published in:Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2011-03, Vol.16 (2), p.250-252
Main Authors: Hanaoka, Naoyoshi, Goto, Tomohiro, Kasai, Tokio, Matsuura, Tetsuya, Nishisho, Toshihiko, Enishi, Tetsuya, Yasui, Natsuo
Format: Article
Language:English
Subjects:
Aged
Biopsy
Bone Neoplasms - diagnosis
Bone Neoplasms - genetics
Case Report
Diagnosis, Differential
DNA, Neoplasm - analysis
Fatal Outcome
Female
Humans
Immunohistochemistry
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neuroectodermal Tumors, Primitive, Peripheral - diagnosis
Neuroectodermal Tumors, Primitive, Peripheral - genetics
Oncogene Proteins, Fusion - genetics
Orthopedics
Positron-Emission Tomography
Proto-Oncogene Protein c-fli-1 - genetics
Reverse Transcriptase Polymerase Chain Reaction
Rheumatology
RNA-Binding Protein EWS - genetics
Sarcoma, Ewing - diagnosis
Sarcoma, Ewing - genetics
Thigh
Tomography, X-Ray Computed
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Summary:Ewing’s sarcoma is a round-cell tumor that commonly arises from bone, but extraskeletal Ewing’s sarcoma (EES) uncommonly occurs in the deep soft tissue of the extremities or paravertebral region [1], and is morphologically indistinguishable from bone lesions. EES is generally found in adolescents and young adults, although a few cases have been reported in older people [2–4]. The optimal treatment and prognosis are not clearly defined because of the rarity of EES. Because the differential diagnosis includes other round-cell tumors with a cytologic appearance similar to Ewing’s sarcoma, cytogenetic and molecular genetic findings of translocations are important in differentiating EES from other round-cell tumors. We present the case of a 67-year-old man with EES in the thigh whose diagnosis was confirmed histologically and cytogenetically. The patient was informed that data concerning the case would be submitted for publication, and he consented.
ISSN:0949-2658
1436-2023
DOI:10.1007/s00776-011-0024-8