Pyoderma gangrenosum in inflammatory bowel disease: The experience at Mater Health Services' Adult Hospital 1998–2009

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with inflammatory bowel disease (IBD). The literature has suggested that PG-IBD is usually associated with ulcerative colitis. We reviewed the PG-IBD cases at the Mater Health Services' Adult Hospital in Brisbane between 19...

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Bibliographic Details
Published in:Journal of Crohn's and colitis 2011-04, Vol.5 (2), p.148-151
Main Authors: Polcz, Margit, Gu, Jennie, Florin, Timothy
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Colitis, Ulcerative - complications
Colitis, Ulcerative - drug therapy
Crohn Disease - complications
Crohn's disease
Cyclosporins - therapeutic use
Extraintestinal manifestations
Female
Humans
Hydrocortisone - therapeutic use
Immunosuppressive Agents - therapeutic use
Inflammatory bowel disease
Male
Mercaptopurine - therapeutic use
Middle Aged
Prevalence
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - complications
Pyoderma gangrenosum
Pyoderma Gangrenosum - complications
Pyoderma Gangrenosum - drug therapy
Pyoderma Gangrenosum - epidemiology
Pyoderma Gangrenosum - etiology
Sex Factors
Ulcerative colitis
Wounds and Injuries - complications
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Summary:Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with inflammatory bowel disease (IBD). The literature has suggested that PG-IBD is usually associated with ulcerative colitis. We reviewed the PG-IBD cases at the Mater Health Services' Adult Hospital in Brisbane between 1998 and 2009 through assessment of a comprehensive web database of IBD patients and verification of chart information of PG-IBD cases. PG-IBD at Mater was associated with clinically mild colonic IBD, with erythema nodosum, and with female sex. All PG-IBD responded eventually to increased immunomodulatory therapy. We discuss why PG-IBD is associated with clinically mild colonic IBD be it ulcerative colitis, Crohn's or indeterminate colitis.
ISSN:1873-9946
1876-4479
DOI:10.1016/j.crohns.2010.10.006