Interaction Between Periodontal Disease and Systemic Secondary Amyloidosis: From Inflammation to Amyloidosis

• Published in: Journal of periodontology (1970) 2011-04, Vol.82 (4), p.566-574
• Main Authors: Cengiz, Murat İnanç, Yayla, Nazır, Cengiz, Kuddusi, Bagci, Hasan, Taşkın, Emre
• Format: Article
• Language: English
• Subjects: Acute-Phase Proteins - analysis; Acute-Phase Proteins - immunology; Acute‐phase proteins; Adult; Aged; Amyloidosis; Amyloidosis - blood; Amyloidosis - complications; Amyloidosis - immunology; Biological and medical sciences; Case-Control Studies; Cohort Studies; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Familial Mediterranean Fever - blood; Familial Mediterranean Fever - complications; Familial Mediterranean Fever - immunology; Female; genetics; Humans; Inflammation - blood; Inflammation - complications; Inflammation - immunology; Male; Medical sciences; Metabolic diseases; Middle Aged; Non tumoral diseases; Other metabolic disorders; Otorhinolaryngology. Stomatology; periodontal diseases; Periodontal Diseases - blood; Periodontal Diseases - complications; Periodontal Diseases - immunology; Reference Values; Turkey
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2010.100439

Background: It has become increasingly clear in recent years that periodontal disease can cause a dramatic increase in the levels of markers of systemic inflammation, and that periodontal treatment can result in reduction in the levels of these markers. We have previously shown that the prevalence of moderate to severe periodontitis was significantly higher in patients with familial Mediterranean fever (FMF) with amyloidosis than in patients with FMF without amyloidosis. Thus, the aim of this study is to investigate if chronic periodontitis is associated with secondary amyloidosis in the Black Sea region of Turkey. Methods: A total of 112 patients with biopsy‐proven secondary amyloidosis (59 patients with FMF, 40 patients who were either chronically infected or had malignant disease, 13 patients with periodontitis) and 22 healthy subjects, were included in this study. Periodontal health and disease were evaluated using gingival index (GI), papillary bleeding index (PBI), plaque index (PI), and periodontal disease index (PDI). The concentrations of serum acute phase reactants (APRs) were measured at baseline and at 4 to 6 weeks after completion of the non‐surgical periodontal therapy. Results: The prevalence of moderate to severe periodontitis was 47.5% in patients with FMF, 72.5% in patients who were either chronically infected or had malignant disease, and 84.6% in patients with periodontitis. Serum levels of APRs in patients with amyloidosis were reduced significantly after non‐surgical periodontal therapy (P