Growth hormone (GH) treatment may cooperate with locally-produced GH in increasing the proliferative response of hippocampal progenitors to kainate-induced injury

Primary objective: This study was designed to investigate the effect of growth hormone treatment on the proliferation of endogenous neural progenitor cells in the dentate gyrus (DG) of the brain stimulated by kainic acid (KA)-induced neurotoxicity. Research design: Neurotoxicity was induced by intra...

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Bibliographic Details
Published in:Brain injury 2011-05, Vol.25 (5), p.503-510
Main Authors: Devesa, Pablo, Reimunde, Pedro, Gallego, Rosalía, Devesa, Jesús, Arce, Víctor M.
Format: Article
Language:English
Subjects:
Animals
Cell Proliferation
Dentate Gyrus - cytology
Dentate Gyrus - drug effects
Dentate Gyrus - metabolism
Excitatory Amino Acid Agonists
Growth hormone
Growth Hormone - metabolism
hippocampus
Kainic Acid
Male
neurogenesis
neuroprotection
Rats
Rats, Sprague-Dawley
Stem Cells - drug effects
Stem Cells - metabolism
Up-Regulation
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Summary:Primary objective: This study was designed to investigate the effect of growth hormone treatment on the proliferation of endogenous neural progenitor cells in the dentate gyrus (DG) of the brain stimulated by kainic acid (KA)-induced neurotoxicity. Research design: Neurotoxicity was induced by intraperitoneal injection of KA. GH treatment lasted 4 days, starting either immediately or after 10 days of administration of the neurotoxic insult. Methods and procedure: Proliferating cells were immunodetected after labelling by in vivo administration of 5-bromodeoxyuridine (BrdU). GH expression was detected by in situ hybridization and immunofluorescence. Main outcomes and results: KA administration stimulated the proliferation of hippocampal precursors and this effect was significantly enhanced by GH treatment. Hippocampal GH expression was also up-regulated in response to KA administration. Conclusions: The findings support the possibility that the proliferative response observed in the hippocampus of rats treated with KA and GH is a consequence of cooperation between the exogenous and the locally-produced hormone and their synergism with other mitogenic factors generated in response to the neurotoxic damage. Therefore, GH treatment could be used to cooperate with other physiological or pathological stimuli in order to promote cell proliferation.
ISSN:0269-9052
1362-301X
DOI:10.3109/02699052.2011.559611