Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: role in functional capacity and mortality

• Published in: European heart journal 2011-04, Vol.32 (7), p.904-912
• Main Authors: JORGE, Luciana, RODRIGUES, Bruno, DE ANGELIS, Kátia, IRIGOYEN, Maria-Cláudia, TEODORO ROSE, Kaleizu, MALFITANO, Christiane, ALBA LOUREIRO, Tatiana Carolina, MEDEIROS, Alessandra, CURI, Rui, CHAKUR BRUM, Patricia, LACCHINI, Silvia, MONTANO, Nicola
• Format: Article
• Language: English
• Subjects: Animals; Autonomic Nervous System Diseases - physiopathology; Baroreflex - physiology; Biological and medical sciences; Body Weight; Cardiac Output - physiology; Cardiology. Vascular system; Coronary heart disease; Echocardiography; Heart; Heart Rate - physiology; Kaplan-Meier Estimate; Male; Medical sciences; Microspheres; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocarditis. Cardiomyopathies; Oxygen Consumption - physiology; Physical Conditioning, Animal; Rats; Rats, Wistar; Regional Blood Flow - physiology; Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism; Vascular Endothelial Growth Factor A - metabolism; Ventricular Dysfunction, Left - physiopathology
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehq244

To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO(2) max), and mortality after myocardial infarction (MI) in rats. Male Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 50-70% VO(2) max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6%) compared with SI (34 ± 5%) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13%) group compared with the SI (54%) group. Early aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.