Two new 5,8-quinoflavans from the leaf of Ilex centrochinensis

Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3′,4′-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4′-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses....

Full description

Saved in:
Bibliographic Details
Published in:Journal of asian natural products research 2011-04, Vol.13 (4), p.341-345
Main Authors: Li, Lu-Jun, Zhang, Yue, Zhang, Peng, Pi, Hui-Fang, Ruan, Han-Li, Wu, Ji-Zhou
Format: Article
Language:English
Subjects:
(2R)-7,3′,4′-trimethoxy-5,8-quinoflavan
(2S)-7-methoxy-4′-hydroxy-5,8-quinoflavan
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Caco-2 Cells
cytotoxic activity
cytotoxicity
Drug Screening Assays, Antitumor
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
General pharmacology
human cell lines
Humans
Ilex
Ilex - chemistry
Ilex centrochinensis
leaves
Medical sciences
Molecular Structure
Natural products
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
spectral analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3′,4′-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4′-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses. Both of them exhibited weak cytotoxic activity against HuH7 cell lines and no cytotoxic activity against CaCO-2 cell lines.
ISSN:1477-2213
1028-6020
1477-2213
DOI:10.1080/10286020.2011.557021